is seen in the adjacent OFC, as well as the striatum. This is especially interesting in light of neuroimaging findings that suggest hyperactivity at rest in the OFC24,25,58,59, while no such evidence exists for the dlPFC (though lateral OFC and dlPFC hypoactivity have been consistently observed in OCD patients during cognitive tasks60,61). Studies directly comparing differential expression in the dlPFC and OFC of the same subjects may clarify whether gene expression changes are global or region specific.
