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Chunk #27 — Discussion — Phenotypic associations

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Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality.
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on suicidality. These methodological differences could explain the inconsistency between our findings and those of the previous meta-analysis. Further, the previous meta-analysis focused on varying degrees of cannabis use (any, chronic, and heavy cannabis use), while our analysis investigated CaD. The genetic basis of substance use, substance abuse, and SDs appears to be partially distinct39–42 and these differences may affect their associations with suicidality. With respect to this issue, an interesting approach for future investigations would be to investigate the association of SD and SUD diagnostic criteria with suicidality.