The polygenic scores for suicide attempt, depression, and PTSD were associated with a lifetime suicide attempt in persons with AD in the meta-analyzed results. Exploration of the ancestry-specific result demonstrate these were primarily driven by the associations in the EUR participants. The lack of associations of PGSs in those of African ancestries likely stems from the relatively small sample sizes of the discovery GWASs [73]. Importantly, in the multinomial logistic regression models, those with AD did not differ in mean levels of AUD PGS regardless of whether they had reported a lifetime suicide attempt. Similar to the logistic regression models limited to persons with AD, those who had attempted suicide had higher suicide and depression PGSs.
