Both psychotic disorders exhibited greater heritability than cannabis phenotypes and were more polygenic than CUD. While the polygenicity findings for SCZ and BIP are in line with previous reports.45 To our knowledge, the polygenicity of LCU or CUD have not been previously estimated. Cannabis phenotypes exhibited distinctive genetic architectures from each other. CUD was more heritable and influenced by fewer genetic variants which maybe reflective of a more specific, clinically defined disorder, potentially more influenced by biological factors like an individuals’ physical response to the consumption of tetrahydrocannabinol46. LCU was less heritable and more polygenic likely reflecting a less specific, heterogeneous, behavioral phenotype more responsive to environmental factors. Moreover, the low discoverability of LCU suggests a large sample size is required to uncover its complete genetic architecture.
