The current study adds support for the shared genetic hypothesis for psychotic disorders and cannabis phenotypes by confirming genome-wide rgs,9,13 identifying local rgs in smaller genomic regions, and discovering 57 distinct shared loci. Positive genome-wide rgs, positive shifts in local rgs, and concordant effects in the majority of lead shared variants for each psychotic-cannabis phenotype pair indicates that, in general, genetic liability to both cannabis use and psychotic disorders increase concurrently. This suggests, genetic factors underlie the robust positive phenotypic association linking both SCZ and BIP with cannabis phenotypes. PGS analyses revealed a link between genetic liability of cannabis phenotypes and psychotic experience in BIP. Although this adds supports to the established cannabis-psychosis connection,8,47 the associations of cannabis use and BIP with and without psychotic experience require validation. Further, shared genes showed significant enrichment in various biological processes. Some enriched gene ontology terms have been linked to cannabis use and psychotic disorders, such as neuron projection,48,49 while for others, such as glycosphingolipid biosynthesis50, the connection to cannabis phenotypes requires further investigations.
