whether pediatricians should be asked to receive and manage results pertaining to adult-onset conditions and about the psychological impact of such information on the family. We further acknowledge that there are groups proposing to avoid this issue when sequencing children by sophisticated masking of off-target genes, making them unavailable for evaluation.34 Nonetheless, we believe that sequencing creates a different calculus than that which was envisioned with predictive testing for a familial condition. In the absence of clarifying data about the actual harms of learning about adult-onset conditions in children, or the actual benefits to parents who might learn previously unsuspected risk information through sequencing of their child, we have recommended disclosure of the conditions, genes and variants listed in the Table for both adults and children who undergo clinical sequencing.
