The return of incidental findings to parents of minor children who undergo clinical sequencing presents difficult issues. The Working Group felt it best not to place arbitrary age restrictions or limitations on the return of incidental (secondary) variants since the variants would likely have implications for others in the family. For example, the sequencing of a child and the discovery of incidental findings that increase the risk of adult-onset cancer predisposition may be medically important to one of the parents of that child. In this scenario, the result has been generated and is fully available. To mask or withhold the incidental finding is to state that the child’s right not to know supersedes the parent’s opportunity to discover a life-threatening risk factor. We recognize that this recommendation differs from those developed around candidate gene testing. There are legitimate concerns about whether pediatricians should be asked to receive and manage results pertaining to adult-onset conditions and about the psychological impact of such information on the family. We further acknowledge that there are groups proposing to avoid this issue when sequencing children
