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Chunk #34 — Limitations

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General and specific functional connectivity disturbances in first-episode schizophrenia during cognitive control performance.
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The main effects on functional connectivity observed in our analyses were robust to different analysis parameter settings. The interaction effect was more sensitive to such variations, suggesting that it may have been present across a more restricted range of network component sizes. In addition, the correlation between connectivity and task performance in control subjects did not survive multiple comparison correction. Replication of these effects in a larger sample is warranted. However, the consistency of our results with past findings, as well as the strength of the connectivity-behavior association (~20% shared variance), suggest that our findings are indeed robust and relevant for understanding the neural basis of cognitive control deficits in schizophrenia.