The Supplementary Note contains an extensive analysis of many of the newly prioritized genes and their brain-related functions. Here we highlight two especially noteworthy regularities. First, whereas previously prioritized genes exhibited especially high expression in the brain prenatally, newly prioritized genes show elevated levels of expression both pre- and postnatally (Fig. 3B). Many of the newly prioritized genes encode proteins that carry out online brain functions such as neurotransmitter secretion, the activation of ion channels and metabotropic pathways, and synaptic plasticity (Supplementary Figure 8).
