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Chunk #59 — Systematic review of fMRI studies — Transition into alcohol use

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The effect of alcohol consumption on the adolescent brain: A systematic review of MRI and fMRI studies of alcohol-using youth.
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Specifically, within the sample of AU youth, B+ youth showed greater BOLD signal during inhibitory trials than non-AU youth in task-relevant regions including the left middle frontal gyrus, right medial temporal lobe and left cerebellum. In the other sample of AU youth, B− youth showed less activation than non-AU youth in task-relevant regions including the right middle frontal gyrus and rostromedial prefrontal cortex. Both groups of AU youth (B+ and B− youth) showed less activation than non-AU youth in the right inferior parietal lobule. Within the sample of AU youth, the B+ group displayed greater activity than the B− group in the right middle frontal gyrus, left middle frontal gyrus, right middle temporal lobe, left cerebellar tonsil and pre-SMA. There were no regions in which the B− youth showed greater activation than the B+ youth. The authors found that, in contrast to the expected pattern, AU youth who transition to having blackouts showed an overall greater pattern of task-relevant response in salient frontal regions. The authors interpret these data (greater activation in light of equivalent behavioural performance) as suggestive of