CHRNB2 (the β2 nicotinic ACh receptor), which are critical for dopamine-dependent locomotor activation after repeated nicotine administration29. Mutations in CHRNA4 cause nocturnal frontal lobe epilepsy type 130 and polymorphisms of CHRNA4 have been reported in association with nicotine dependence31–33. HRH3 encodes the histamine receptor H3, which is ubiquitously released from neurons, mast cells, and enterochromaffin-like cells, and can regulate neurotransmitter release34. The significant co-expression between CHRM3 and GABRG2, CHRNA4, and HRH3 reflects the critical function of CHRM3 in the brain, which raises the question of whether, in response to long-term cannabis use, there is crosstalk between CHRM3 and the three noted genes in Ca-HL.
