Multiple lines of evidence support the involvement of CHRM3 in schizophrenia, which has some symptoms phenotypically close to Ca-HL. In a neural connectivity GWAS in a Chinese schizophrenia case–control sample, CHRM3 variant rs6700381 was significantly associated with abnormal thalamo-orbital FCTX functional connectivity in first-episode schizophrenia patients35. In a multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls36, 1 SNP rs72769124 near CHRM3 was possibly associated with schizophrenia (P = 5.5 × 10−7; Supplementary Fig. S5). According to the Brainiac database, neither rs6700381 nor rs72769124 is a CHRM3 eQTL among ten healthy brain tissues. These risk variants may, however, be CHRM3 eQTLs under different conditions or environmental exposures or in different brain regions, or in different populations.
