For meta-analyses of MDD-META and SR-Depression, we also used available GWAS summary statistics from 23andMe, UKB, PGC, and FinnGen (Table 1). Genetic correlation was conducted between the phenotypes to be meta-analyzed together to quantify potential heterogeneity between the studies to be combined. These studies used a variety of phenotype definitions, with some combining clinical diagnosis of depression based on structured interview and other broader methods,7 such as self-reported treatment,7 or self-reported diagnosis items on questionnaires.9 This analysis is discussed in greater detail in the methods, but the genetic correlations between all traits ranged from 0.71–0.84.
