In this study, family-based association analysis was performed in the OZALC sample by using the PBAT v3.61 (Hoffmann and Lange, 2006), which can handle nuclear families, as well as extended pedigrees. For family-based association analysis, the additive model was applied. To deal with the multiple testing in the family-based association study, we used software QVALUE (http://genomics.princeton.edu/storeylab/qvalue/) to calculate the false discovery rate (FDR) (Storey, 2002).
