Chunk #10 — 2. Materials and methods — 2.2. Statistical analyses — 2.2.4. Cis-acting expression of quantitative locus (Cis-eQTL) analysis on the risk SNPs in two primary human cells
To examine whether the risk SNPs (listed in 1st column in Tables 2, 3 and 4) influenced the transcript-level expression changes of local genes (listed in 4th column in Tables 2, 3 and 4), we also tested the associations between the genotypes of these risk SNPs and the expression levels of these genes in two European samples. Expression data in 93 autopsy-collected frontal cortical brain tissue samples with no defined neuropsychiatric condition and 80 peripheral blood mononuclear cell (PBMC) samples collected from living healthy donors were evaluated (Heinzen et al., 2008). Each of these associations was analyzed using a linear regression model by correcting for age, sex, source of tissues, and principle component scores.
