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Chunk #33 — Results — Expression analysis of rs4714329 in brain tissue databases

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Genome-wide association study of antisocial personality disorder.
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The most significant variant of the replication and meta-analyses for ASPD, rs4714329 resides in the proximity of the genes LINC00951, LRFN2, RP11-552E20.1 and TDRG1. LINC00951 and LRFN2 are expressed mostly in the brain, especially in the cortex and testis. TDRG1 gene is expressed mostly in testis and in the brain. Thus, we investigated in the GTEx Portal and in the Braineac database the possible association of rs4714329 with the nearby residing genes' expression levels in all of the available brain tissues and in testis (testis only in the GTEx Portal; Supplementary Information).