In the GTEx Portal, the most significant association was achieved with LINC00951 gene expression in cerebellum (N=103) with the β of 0.51 and a P-value of 2.0 × 10−6. LRFN2 and TDRG1 gene expressions revealed association in the cerebellar hemisphere (N=89; P-value=2.0 × 10−5 and β=0.56, P=4.0 × 10−5 and β=0.51, respectively; Supplementary Table 6a). In Braineac, no data were available for LINC00951, but rs4714329 was associated most significantly (P=7.4 × 10−4) with LRFN2 expression in cerebellum (N=130), although consistently with the GTEx Portal, LRFN2 is mostly expressed in the cortex. For TDRG1 expression in Braineac, the most significant (P=3.8 × 10−3) association was observed in occipital cortex (OCTX, N=129; Supplementary Table 6b). Neither databases had data available for RP11-552E20.1 gene expression; in Braineac, no data were available for LINC00951, and RP11-552E20.1 genes. Thus, the results revealed that rs4714329 associated to expression of the nearby located genes in brain so that the risk allele G of rs4714329 was found to correlate with reduced levels of LINC00951, LFRN2 and TRG1 mRNAs in cerebellum and of TDRG1 in occipital cortex.
