The results from this first GWAS on ASPD reveal genome-wide significant and replicable associations for variants residing on chromosome 6p21.2. According to our linkage investigation, our best hit, rs4714329 is in considerable LD with several polymorphisms of the LINC00951 gene, and not up to the same level with the polymorphisms of the other genes in that genomic region, suggesting that the LINC00951 gene is the strongest candidate for the signal origin. However, analysis of the gene expression data from the GTEx and Braineac databases revealed equally strong associations between rs4714329 and the expression levels of three nearby genes, namely LINC00951, LRFN2 and TDRG1, in tissues from cerebellum, of which the LINC00951 association was the strongest in the cerebellum and LRFN2 in the cerebellar hemisphere. Although cerebellum has traditionally been linked to motor control, it has also been suggested to be involved in cognition31 and personality,32 as well as autism spectrum disorders33 and psychosis.34 Most interestingly, Leutgeb et al. reported an altered cerebellum–amygdala connectivity among violent offenders, although their study excluded psychopathic or personality-disordered individuals.35 Although there was no correlation of
