occur in the APPswe mice, at least not until very late in life (Borchelt et al., 1996). Caution should be taken as for the interpretation of the observations presented in these studies. Thus for example, some of the studies depend on BrdU alone for the assessment of newly formed cells in the SGL and/or SVZ. Such proliferating cells may include glia and/or peripheral immune cells that do not belong to the neural progenitor cell population. In order to determine the fate of neural progenitor cell proliferation in these mice, further examination of neural progenitor cell marker, such as nestin or cell lineage-specific markers should be used.
