Denver, Colorado DNA samples from blood and clinical data were provided by the University of Colorado Cancer Center under COMIRB protocol 08–0380. Blood samples were collected from 1217 patients diagnosed with different diseases enrolled in any of 20 clinical research trials carried out at Colorado SPORE protocols between 1993 and 2008. Of these 1217 patients, 246 were LC cases and 971 had never had LC at the time of sample shipment. LC cases were identified either from data matches with the Colorado Central Cancer Registry or by having malignant lung tissue collected via enrollment in a surgical protocol. Work in this study was limited to cases and controls of self-reported European ancestry (195 cases and 798 controls).
