Zaragoza, Spain The Spanish study population was previously described.22 The 455 LC cases were recruited from the Oncology Department of Zaragoza Hospital in Zaragoza, from June 2006 to June 2009. The 1444 Spanish controls were patients at the University Hospital in Zaragoza for diseases other than cancer, between November 2001 and May 2007. Study protocols were approved by the Institutional Review Board of Zaragoza University Hospital.