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Chunk #20 — GxE Studies Using Inferred Measures of Genotypic Variation — Environmental Moderators of Inferred Genotype — Marital Status

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The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review.
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One twin study has investigated this issue using a GxE approach. Heath, Jardine, & Martin (1989) found that marital status moderated the manifestation of genetic influences on alcohol consumption among female twins from Australia. Genetic influences explained a greater proportion of the variance in weekly alcohol consumption among unmarried females (younger cohort, 60%; older cohort, 76%) compared to married females (younger cohort, 31%; older cohort, 46–59%). There was no evidence for shared environmental influences, and the remainder of variance was attributable to individual-specific environment.