The 6p21.33 association could be mediated through any number of transcripts mapping to the region of LD. BAT3 represents a strong candidate for lung cancer susceptibility as it is implicated in apoptosis and the protein complexes with E1A-binding protein p300, required for acetylation of p53 in response to DNA damage(14). As the region of LD at 6p21.33 is extensive and contains a large number of transcripts, dissection and elucidation of the causal variant make this the most refractory to interrogation.
