No single study can disprove a meta-hypothesis in psychiatry, and our conclusions are bounded by the statistical power of the ISC sample. However, it is notable that the ISC GWAS results do not support enrichment of schizophrenia susceptibility loci within the candidate genes. These results suggest – but do not prove – that many traditional ideas about the genetic basis of schizophrenia may be incorrect. Indeed, the singular advantage of genomic surveys is that they are unbiased by prior knowledge and can yield novel and unexpected findings. Given current knowledge of the genetic architecture of schizophrenia and the capacity to assess common and rare variation across the genome, it is possible that the next few years will lead to marked changes in major hypotheses about the genetic basis of schizophrenia.
