The ALSPAC sample included 15,247 pregnancies from women residing in Avon, UK with expected dates of delivery between April 1991 and December 1992, resulting in 15,458 fetuses. Of this total sample of 15,458 fetuses, 14,775 were live births and 14,701 were alive at 1 year of age. Additional details regarding the sample can be found in Boyd et al. [25]. Ethical approval for the study was obtained from the ALSPAC Ethics and Law Committee and the Local Research Ethics Committees. In the present study, we used data from unrelated participants who completed an alcohol assessment at 16 and/or 18 years of age (5952 participants) for whom there were also genotypic data (n = 4304). Please note that the study website contains details of all the data that is available through a fully searchable data dictionary (http://www.bris.ac.uk/alspac/researchers/data-access/data-dictionary).
