In a GWAS of fronto-central fast beta EEG in families of EA, we report a genome-wide significant signal in an intronic region of DSE (dermatin sulfate) on 6q22. The most significant SNP, rs2252790 (p<2.6×10−8; MAF: 0.36), was positively associated with fast beta EEG (β: 0.135). Taken together, data from Brainiac and GTEx suggest that rs2252790 is associated with the expression of DSE/TSPYL1 (note, that DSE and TSPYL1 have overlapping regions) and ROS1 in several brain tissues. Notably, rs2252790 is an eQTL for DSE/TSPYL1 mRNA expression in hippocampus tissue and for ROS1 expression in temporal cortex tissue. Both of these brain regions may be particularly relevant to beta EEG. It has been suggested that the beta rhythm may serve to establish transient physiological connections, reflected in coherence at the beta frequency among neurons in the hippocampus and related structures (Leung, 1992b; Vecchio et al., 2016b). Further, the high-frequency (i.e., fast beta) oscillations, often referred to as ‘rapid discharges’, have often been associated with seizure generation. Evidence from hippocampal slices shows that neuroelectric bursts in CA1 pyramidal cells are caused by highly
