Vecchio et al., 2016b). Further, the high-frequency (i.e., fast beta) oscillations, often referred to as ‘rapid discharges’, have often been associated with seizure generation. Evidence from hippocampal slices shows that neuroelectric bursts in CA1 pyramidal cells are caused by highly synchronized β-band activity (Netoff and Schiff, 2002). Further, impairments observed in temporal lobe epilepsy (TLE) and Alzheimer’s disease have links to these brain structures and fast beta EEG. For example, lesions due to TLE typically involve mesial structures of the temporal lobe, particularly the amygdala and hippocampus (Kiernan, 2012). These structures play a central role in learning and memory (Leritz et al., 2006), while additionally involving sub-domains of working memory and executive functions (Stretton and Thompson, 2012; Zhao et al., 2014). Seizures caused by mesial TLE often involve fast frequency oscillations in the range of EEG fast-beta (Spencer et al., 1992; Bartolomei et al., 2004; Bartolomei et al., 2008). Further, researchers have hypothesized that cognitive impairments observed in Alzheimer’s disease may involve disrupted functional connectivity between frontotemporal and frontoparietal regions related to beta (and alpha) frequency EEG (Hsiao et al., 2013). These findings highlight that the brain regions implicated by the mRNA expression associated with DSE variant rs2252790 (hippocampus, temporal
