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Chunk #44 — Postural Stability — Measures in rodents

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Human and laboratory rodent low response to alcohol: is better consilience possible?
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yes

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For preference drinking, there were comparable data for 6 inbred strains. For 16 measures, there was little to no evidence of correlation across strains (*r*< 0.37). For only one measure was there the hint of a relationship. Preference drinking was negatively correlated with improvement of accelerating rotarod performance after a low dose of alcohol (r = −.69, p = .13). For withdrawal severity, with data from 7 inbred strains, only the acute hypothermic response was related (r = −.70, p = .08). This latter negative relationship, however, is not consistent with earlier reports that WSP and WSR mice do not differ in sensitivity to alcohol on a number of the same measures assessed in the inbred strain panel, including acute hypothermia (Metten, Crabbe 1996). These correlations did not reach statistical significance, which is not surprising given the few data points available, and would need to be tested in a larger number of strains. But, overall, they do not help in the selection of one measure of intoxication in mice over another for future studies. Neither were any of the measures