analogous to a stratified Cox-regression with recurrent events.24 As a recurrent-event approach, our analysis allowed for incorporation of time (days since index event) as a covariate, mitigating secular confounding that is often a concern with single-event, case-control studies.24,25,26 We controlled for secular time trends using restricted cubic splines.27 Unadjusted models included only OUD medications, whereas adjusted models controlled for exposure medications commonly associated with alcohol poisonings.23 All P values were derived from 2-sided tests, with significance reached at P < .05. Statistical analysis was performed using SAS statistical software version 9.4 (SAS Institute) from June 26 through September 28, 2020.
