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Chunk #13 — METHODS — Subjects

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Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking.
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Family history of alcoholism (FHA) was assessed using the Family History Assessment Module (FHAM) (Rice et al., 1995). Family history of alcoholism was defined as positive if: 1) one 1st degree, and 2) at least another 1st or 2nd degree biological relative was reported to have alcohol dependence (lifetime). Family history of alcoholism was defined as negative if no 1st or 2nd degree relatives were reported to have alcohol dependence (lifetime). Subjects not meeting definitions either for family history positive or negative were excluded from the study. Recent drinking history was assessed for the 30 days prior to the interview using a Timeline Follow-Back (TLFB) (Sobell et al., 1988). Four measures were derived from the TLFB (drinking days, drinks per drinking day, heavy drinking days, and total drinks). Subjects were asked about both the volume and type of alcohol they consumed, and their responses used to estimate the number of standard drinks (12 g of ethanol) recorded in their TLFB.