All interviews and testing were conducted at the Indiana Clinical Research Center by trained research technicians. Inclusion criteria were good health as determined by physical exam, a blood test of liver function indices, and subject-reported medical history and consumption of at least 17 drinks in the past month. Exclusion criteria, all based upon subject reports, included current or prior history of any serious disease (including central nervous system, cardiovascular, respiratory, gastrointestinal, hepatic, renal, or endocrine), positive hepatitis or HIV test, alcoholism in the biological mother during pregnancy (to minimize potential effects of Fetal Alcohol Syndrome Disorder), current or prior history of severe alcohol-induced flushing reactions, current or prior history of Axis-I psychiatric illness including alcohol or drug dependence (but not alcohol abuse) assessed using the Semi-Structured Assessment of the Genetics of Alcoholism (SSAGA) (Bucholz et al., 1994), use of medications known to interact with alcohol within 2 weeks of the study; and females who were or intended to become pregnant. In addition, subjects were excluded if, on the day of testing, they had a positive BrAC, presence of illicit drugs on urine drug screen, or, for females, a positive urine pregnancy (hCG) test.
