In the current study, we extracted and divided the CC fibers into seven regions based on the cortical projection regions, and investigated the relationship between the FA values of the CC fibers and cognitive function in schizophrenia. In the SZ group, FA values of the CC that connects the bilateral temporal lobe cortices associated with executive function scores, and FA value of this tract was significantly decreased compared to the HC group. These results indicate an association between microstructural abnormalities of the CC white matter and cognitive dysfunction in schizophrenia.