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Chunk #27 — DISCUSSION

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Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: A tract-specific analysis study.
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In the current study, we found a statistically significant association between white matter abnormalities and executive function impairment. Impairment in executive function is one of the most common dysfunctions observed in disease courses of schizophrenia (Orellana & Slachevsky, 2013). We assessed executive function using the Tower of London test. The Tower of London test requires several cognitive processes including working memory (Elliott, 2003), processing speed, response inhibition (Asato, Sweeney, & Luna, 2006; Zook, Davalos, Delosh, & Davis, 2004), and visuospatial processing (Newman, Carpenter, Varma, & Just, 2003), necessitating functional coordination among multiple cortical and subcortical regions (Unterrainer & Owen, 2006). As white matter fibers connect brain regions, many studies have reported a relationship between white matter abnormalities and cognitive function in schizophrenia (Canu, Agosta, & Filippi, 2015). Executive dysfunction of schizophrenia has been reported to be associated with white matter abnormalities in major fiber bundles that connect frontal and temporal lobes, such as superior longitudinal fasciculus and uncinate fasciculus (Kubicki et al., 2002, 2003; Nestor et al., 2004; Pérez‐Iglesias et al., 2010). In schizophrenia, associations also have been reported between