A series of 8 (time) × 2 (gender) × 2 (ADH1B gene status) mixed factorial ANOVAs were then conducted to examine change in alcohol response measures (sedation, stimulation, and pulse rate) by ADH1B gene status. For these analyses, BrAC at the 60 minute time point was included as a covariate, as this time point represented the average peak BrAC for most participants.