SNPs3D aims at integrating all of the available data relevant for assessing the likely role of particular genes and SNPs in a disease. The emphasis is on providing the users access to as much of the underlying information as possible, so that they may make informed judgments. To this end, in addition to SNP impact analysis, links are provided to relevant abstracts, the GAD [47,48], OMIM [49,50] and HGMD [1,51] disease databases, GO annotation [52,53], expression profile data [54], and mouse knockout results [55]. Data are updated regularly. Exploration of gene networks and access is to all information is facilitated by a Java based graphical interface.