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Chunk #35 — Results — Statistical Analyses — Novelty sources

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Novelty P3 reductions in depression: characterization using principal components analysis (PCA) of current source density (CSD) waveforms.
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The prominent, novelty vertex source (241) was markedly reduced in patients (cf. Table 3 and Figure 5, column 1), and was preserved when age was used as a covariate as well as after age differences were eliminated by excluding the 26 oldest participants, F(1,70) = 4.232, p = .04. This group difference did not reflect activity in the secondary, frontal source of factor 241, which showed an effect in the opposite direction. In marked contrast, the subsequent P3 source (343) did not differ between groups for novel stimuli, either at midfrontal or posterior sites.