iGluRs play key roles in excitatory synaptic signaling and plasticity. Glutamatergic synapses in GABAergic interneurons often contain higher proportions of CP-AMPARs and GluN2B-NMDARs, although the ratio between the two types of AMPARs and NMDARs vary significantly among different cell populations (Akgul and McBain, 2016). Substantiating previous results from hippocampal interneurons (Akgul and McBain, 2016), we found that the mRNA levels and relative ratio of CP- vs CI-AMPAR subunits in PCPs vary in a highly cell type-dependent pattern (Figure 4A–D, Figure S4A). These results suggest cell type-dependent composition and correlation of AMPA and NMDA receptor pore-subunits, especially with regard to the relative abundance and ratio of CP- vs CI- AMPARs and 2B- vs 2A- NMDARs.
