Chunk #16 — RESULTS — Differential expression of cell adhesion molecules and carbohydrate modifying enzymes suggests large capacity for cell surface and extracellular matrix labels
We further discovered prominent differential expression in two families of carbohydrate modifying enzymes, sulfotransferases (AUROC=0.88) and sialyltransferases (AUROC=0.85), that may increase the molecular diversity of glycosylated CAMs and proteoglycans on cell membrane and in extracellular matrix (Figure 3F; Figure S3D). This suggests that each PCP might produce a characteristic cell coat through distinct carbohydrate modification patterns to diversify proteoglycans that facilitates or prevents cell interaction at a distance.
