Information about basic pathways of risk can be used to develop more tailored and personalized prevention intervention efforts (Dick & Hancock, 2015). For example, initial studies of prevention and intervention efforts tailored towards pathways of risk for the development of substance use problems have shown great potential in preventing and reducing substance use and problems. School-based prevention programming tailored to personality profiles at risk for alcohol problems (e.g., anxiety sensitivity, sensation seeking, impulsivity) has shown significant effects on reducing adolescent alcohol related behavior (Conrod et al., 2013, Conrod et al., 2006, O’leary-Barrett et al., 2013). Among college students, a tailored prevention program surrounding low level of response to alcohol (LR), a genetically influenced biological risk factor for heavy drinking and alcohol problems (Schuckit et al., 2009), yielded significant reductions in heavy drinking among those who carried the risk factor compared to a standard non-tailored prevention program (Schuckit et al., 2015, Schuckit et al., 2012).