There exist only a few studies that examine the relationship between unilateral MTL damage and functional connectivity within the DMN, and even fewer relating functional connectivity changes to specific neuropsychological profiles (Holmes et al., 2014; Holmes et al., 2013; McCormick et al., 2013a; Voets et al., 2009; Voets et al., 2012; Voets et al., 2014). For example, functional connectivity changes seen in mTLE (described below) can be attributed to changes in grey matter volume in constituent regions (Holmes et al., 2013; Voets et al., 2012). Further, linking functional connectivity to episodic memory capacity, we showed in an earlier study that stronger connectivity between the posterior cingulate cortex and the hippocampus (PCC–HC) on the epileptogenic side was associated with better material-specific memory capacity, and with greater postsurgical memory decline (McCormick et al., 2013a). In agreement with the idea that network integrity reflects cognitive capacity more accurately than focal integrity, the correlation between PCC–HC connectivity and episodic memory capacity was stronger than the relationship between hippocampal volume and episodic memory (i.e., focal structural integrity) and stronger than the relationship between hippocampal fMRI
