reflects cognitive capacity more accurately than focal integrity, the correlation between PCC–HC connectivity and episodic memory capacity was stronger than the relationship between hippocampal volume and episodic memory (i.e., focal structural integrity) and stronger than the relationship between hippocampal fMRI activation and episodic memory capacity (i.e., focal functional integrity as reported by Bonelli et al., 2010). Nonetheless, our previous study only focused on a single connection, PCC–HC, neglecting the overall functional status of the DMN. Whereas no study has yet related whole DMN integrity to episodic memory capacity to our knowledge, alterations of DMN connectivity and other functional networks underlying memory have been shown in mTLE (Zhang et al., 2010; Cataldi et al., 2013; Addis et al., 2007; Protzner and McAndrews, 2011; Pittau et al., 2012). Importantly, those networks are characterized by not only connectivity decreases but also increases (McCormick et al., 2013a; Addis et al., 2007; Bettus et al., 2010; Maccotta et al., 2013; Morgan et al., 2011) as predicted by virtual focal lesions to the DMN in computational models (Alstott et al., 2009). For example, whereas healthy controls rely on a hippocampal-centric effective network during autobiographical memory retrieval, patients with left mTLE bypass the affected hippocampus relying instead
