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Chunk #5 — Introduction

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Linking DMN connectivity to episodic memory capacity: what can we learn from patients with medial temporal lobe damage?
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predicted by virtual focal lesions to the DMN in computational models (Alstott et al., 2009). For example, whereas healthy controls rely on a hippocampal-centric effective network during autobiographical memory retrieval, patients with left mTLE bypass the affected hippocampus relying instead on increased intrahemispheric connectivity between posterior retrosplenial cingulate and anterior prefrontal cortices (Addis et al., 2007).