For each GABAB1 exon and intron, we assessed expression changes in alcoholic brains. From genome wide exon and intron RPGMs, 23 GABAB1 exons were differentially expressed in alcoholic brains (Table S4 in Supplement 1). Among them, 9 exons showed increased expression and 2 exons showed decreased expression while 12 were unchanged in alcoholics. Based on the changes in expression and direction of change, the exons were grouped into 5 groups: exons 7-8, exon 10, exons 11-12, exons 14-16, and exon 17. Within groups, the changes in expression (Figure 6) and direction (Table S4 in Supplement 1; Figure 7) were similar. The groups were separated by discontinuous expression patterns.
