Third, we evaluated a human single-nuclei RNA-seq dataset consisting of 15 different cell types from cortex and hippocampus 42 (Figure 4A and Table S9). We replicated our findings with psychiatric and cognitive traits being associated with pyramidal neurons (excitatory) and interneurons (inhibitory) from the somatosensory cortex and from the CA1 region of the hippocampus. We also replicated the association of Parkinson’s disease with oligodendrocytes (enteric neurons and cholinergic and monoaminergic neurons were not sampled in this dataset). No cell types reached our significance threshold using specificity metrics computed within-neurons, possibly because of similarities in the transcriptomes of neurons from the cortex and hippocampus.
