Fourth, we evaluated a human single-nuclei RNA-seq dataset consisting of 31 different cell types from 3 different brain regions (visual cortex, frontal cortex and cerebellum) (Figure 4B and Table S10). We found that schizophrenia, educational attainment, neuroticism and BMI were associated with excitatory neurons, while bipolar was associated with both excitatory and inhibitory neurons. As observed previously 11,17,31, Alzheimer’s disease was significantly associated with microglia. Oligodendrocytes were not significantly associated with Parkinson’s disease in this dataset, again possibly because the spinal cord, pons, medulla and midbrain were not sampled. No cell types reached our significance threshold using specificity metrics computed within neurons in thid dataset.
