Chunk #31 — Results — Replication in other single-cell RNA-seq datasets

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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.

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Most cell type-trait associations were attenuated using human single-nuclei data compared with mouse single-cell RNA-seq data, suggesting that the transcripts that are lost by single-nuclei RNA-seq are important for a large number of disorders and/or that the controlled condition of mouse experiments provide more accurate gene expression quantifications (see Discussion and Figure S19).