Collectively, these data show that AM3506-induced elevation of anandamide in the BLA is associated with an enhancement of LTDi, but less with other forms of synaptic plasticity, in this brain region. This profile is consistent with a lasting suppression of GABA release from amygdala interneurons, one consequence of which could be relief of a tonic inhibitory constraint on amygdala neurons engaged in the formation of extinction memories.14 Direct functional evidence in support of this mechanism will require additional study.
