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Chunk #25 — Materials and Methods — The SCAN Database

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Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS.
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Since SNPs in probes can generate spurious eQTL signals by affecting hybridization, we downloaded SNP data from dbSNP (build 129, human genome assembly build 36) to identify probes in probesets that hybridize to regions containing SNPs. The genomic coordinates of the probes were downloaded from the Affymetrix website (http://www.affymetrix.com). We filtered these probes before conducting the expression analyses generating the results served in SCAN.