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Chunk #52 — STAR METHODS — METHOD DETAILS — Polygenic score derivation and validation

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Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.
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For our score derivation, we used summary statistics from a recent genome-wide association study (GWAS) for body mass index (BMI) including up to 339,224 individuals and a linkage disequilibrium reference panel of 503 European samples from 1000 Genomes phase 3 version 5 (Locke et al., 2015; The 1000 Genomes Project Consortium, 2015). DNA polymorphisms with ambiguous strand (A/T or C/G) were removed from the score derivation.