Polygenic scores provide a quantitative metric of an individuals inherited risk based on the cumulative impact of many common (minor allele frequency ≥1%) variants. Weights are generally assigned to each genetic variant according to the strength of its association with a given trait (effect estimate). Individuals are scored based on how many risk alleles they have for each variant (e.g. 0, 1, 2 copies) included in the polygenic score.
